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Due to the inherent long scan times, single and multidirectional cine phase-contrast MRI [1] has limited practical value in a clinical setting [2]. Using parallel imaging combined with constrained reconstruction procedures [3], acceleration factors on the order of 4-6 have been shown practicable for flow quantification [4]. Recently, kt PCA(5) was proposed to further constrain reconstruction. By using principle component analysis (PCA) on the training data, the number of unknowns to be solved for can be reduced thereby permitting acceleration factors excelling those of previous methods. In this work, the k-t PCA method is extended by introducing spatial compartment-specific basis sets to improve reconstruction accuracy at very high undersampling factors (method termed k-t PCA+ hereafter).

Spatio-temporally constrained reconstruction for highly accelerated flow MRI