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Methods We prospectively investigated 36 patients with biopsyproven amyloidosis in a 1.5 T scanner. Amyloidosis type was AL in 32, AA and TTR in 2 cases, each. We obtained SSFP-based long axis cine loops and T2-weighted triple inversion fast spin echo images in short axis (slice thickness 20 mm, TE 64 ms, TR = 2 RR), followed by inversion recovery gradient echo images after 0.2 mmol/kg bw GdDTPA. LV mass, volume, ejection fraction and left atrial area were measured based on biplanar long axis images. T2 ratio was computed as myocardial over skeletal muscle signal intensity in the same image to exclude effects of heart rate. Late enhancement images were evaluated visually for the presence of hyperintense lesions. Outcome was confirmed by chart review and contact of the referring clinician. Results were compared between surviving and deceased patients. In Kaplan-Meyer and Cox regression analysis we tested the predictive value for survival.

Hypointense T2 signal predicts worse prognosis in cardiac amyloidosis