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2) FeCo/GC nanocrystals Composed of an iron-cobalt core encapsulated by a biocompatible graphite shell (size 7 nm) with Cy5.5 attached for fluorescence imaging. FeCo/GC have superior MRI properties with both cellular imaging and heating attributes. A higher dose (25 mgFe/kg) was used for detection at 3 T than 7 T (6 mgFe/kg). 3) MRI 2 weeks post-ligation, mice (n = 4) were imaged on a whole-body 3 T MRI scanner (Signa HDx, GE Healthcare) with installed gradients (50 mT/m, 150 T/m/s) and a custom 3 cm surface RF coil. As a comparison, another group of mice (n = 3) were imaged on a small-bore 7 T system (30 cm bore magnet, Varian Inc. plus GE "Micro-Signa" environment), with a 9 cm gradient insert (770 mT/m, and 2500 T/m/s, Resonance Research, Inc.) and a custom 6-cm RF coil. Similar gradient echo sequences were used (3 T: TR/TE = 100 ms/10 ms, slice thickness = 1.0 mm, from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010

Feasibility of a whole-body 3 T MRI system for detecting macrophages in mouse carotid atherosclerosis using feco/graphite core-shell nanocrystals