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Post myocardial infarction (MI) activated matrix metalloproteinases (MMPs) degrade the extracellular matrix (ECM) and alter the tissue microstructure (TMS). Diffusion Tensor MRI (DT-MRI) yields diffusivity and anisotropy indices that characterize the TMS. Our previous studies in pigs post-MI have showed that gross spatial and temporal changes in mean diffusivity () and fractional anisotropy (FA) correlate with MMP activation assessed with a 99 mTc-labeled radiotracer (RP805) targeted at activated MMPs.

Regional matrix metalloproteinase activation correlates with microstructure diffusion tensor indices post myocardial infarction