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Methods Patients with clinical indication for coronary x-ray angiography underwent previously adenosine-stress CMR at 1.5 T (Intera, Philips Medical Systems) and 3 T (Achieva, Philips Medical Systems) within 48 hours. Within 72 hours after the last CMR examination coronary angiography was performed in these patients. A SSFP-based sequence was used for perfusion imaging at 1.5 T and a gradient-echo sequence at 3 T. Three short axis distributed along the left ventricle were acquired, consequently after three minutes of adenosine infusion at a constant rate (140 μg/kg/min) to visualize myocardial first-pass of 0.075 mmol/kg Gadolinium-based contrast agent (Dotarem, Guerbet). Ten minutes later the same perfusion sequence using a second contrast bolus was performed during rest. All CMR images were analyzed by two blinded and experienced readers in consensus for presence of hypoperfusion during stress perfusion. Perfusion sequences were evaluated using the 17-segment-model. A relevant stenosis was defined by QCA as luminal reduction ≥70% in a vessel with ≥2 mm diameter.

Adenosine-stress magnetic resonance perfusion for detection of coronary artery stenosis at 3 T is not inferior to 1.5 T