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Results In six volunteers a shift of shortening curves towards earlier heart phases (left-shift) and a decrease in the areaunder-the-curve (work) was noted. In three volunteers no significant change in phase but decrease in amplitude and work was observed. One proband showed a significant right-shift (negative inotropy) from the start. This proband was investigated a second time starting at a very low dose of 5 μg/kg/min resulting in a left-shift up to 25 μg/kg/min and a reproducible right-shift from 50 to 150 μg/kg/min. Vital parameters remained stable at all dosages in all volunteers.

Accelerated whole-heart 3D CSPAMM reveals impact of beta-blocker therapy on myocardial architecture