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and purpose Molecular imaging and nanomedicine approaches to the diagnosis, monitoring and treatment of cardiovascular diseases, e.g. atherosclerosis, could have significant consequence on medical practice and outcomes. Due to the exquisite sensitivity of MR to magnetic field disturbances of iron oxides (IO), a variety of IO-based agents have been utilized. However, despite many elegant new imaging techniques, the highly-sensitive detection and visualization of IO still depends on the disruption of the local magnetic field. Contrary to typical IO agents, we have presented a novel colloidal iron oxide nanoparticle (CION) that encapsulates multiple magnetite nanocrystals suspended in oil, encased in a lipid membrane thereby reducing T2* effects such that T1 effects can be detected. The purpose of this work was to develop a CION with improved longitudinal relaxivity (r1) and the ability to carry drugs.

CION v2.0: a better way to T1 enhancement with iron oxides