English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Methods Consecutive ACHD patients (N = 15) were studied with cardiac MRI (Philips Achieva 3.0 Tesla) to quantify ventricular volume and function, as well as late gadolinium enhancement (LGE). T1 measurements were made with a Look-Locker technique, ie GRE sequence with a non-slice selective inversion pulse followed by segmented GRE acquisition for 20–24 cardiac phases. (temporal resolution 40 ms, TR/TE/FA = 3.4/1.7/12, slice thickness 8 mm, 170 × 140 matrix, FOV 400 × 320 – 400, SENSE factor 2) The sequence was performed before and at various intervals 3–15 minutes after injection of Gadolinium-DTPA (total dose 0.1 mmol/kg). For each T1 sequence a region of interest was defined for the myocardium of the systemic ventricle and blood pool. Intensity vs. time curves were used to define T1, and 1/T1 or RT1. The slope of the linear relationship of RT1 values for myocardium vs. blood gave the partition coefficient of Gadolinium (lambda). VdGd was calculated as lambda × (1-Hct/100). Results were compared to normal controls (N = 10) and patients with acquired heart failure (N = 4). Results VdGd was significantly elevated in ACHD patients compared to controls (32 ± 5% vs. 25 ± 2%, p < 0.001). There was a negative correlation between VdGd and systemic ventricular ejection fraction (R = -0.43). VdGd was comparable to patients with acquired heart disease (29 ± 5%, p = ns; p = 0.016 vs. controls), similar to our previously reported values in cardiomyopathy patients. No large macroscopic areas of LGE were present to explain the findings. VdGd was highest in patients with transposition of the great arteries (35 ± 5%) and Eisenmenger syndrome (34 ± 5%).

journal of cardiovascular magnetic resonance

216 Beyond late gadolinium: ventricular dysfunction in adults with congenital heart disease is associated with diffuse myocardial fibrosis as shown by the volume of distribution of gadolinium