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A novel elastin-binding, Gadolinium-based low molecular weight contrast agent, BMS753951 (Bristol Myers Squibb, Billerica, MA) may be useful for visualization of the artery wall by delayed-enhancement magnetic resonance imaging (MRI). Synthesis and degradation of the extracellular matrix (ECM), including elastin, plays a central role in the natural progression of atherosclerosis. In particular, excessive ECM degradation in the advanced plaques has been suggested to be associated with plaque instability.

journal of cardiovascular magnetic resonance

153 MR vessel wall imaging of the descending aorta using an elastin-binding contrast agent in an ApoE-/- TFDeltact double knockout mouse model of advanced atherosclerosis