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Smooth muscle cell proliferation and extracellular matrix (ECM) synthesis/turnover are thought to play an important role in vessel wall repair after vascular injury. Recently, we identified the cysteine-rich-protein-2 (CRP2) as novel and specific molecular effector of the NO/cGMP/ cGMP-dependent-protein-kinase-I (PKG) signaling in vascular smooth muscle. To elucidate whether CRP2 contributes to the postulated pro-proliferative/proatherogenic effect of PKG, we established a CRP2-deficient mouse line by targeted deletion of the exons 2–7 in the CRP2-gene. With the simultaneous development of a novel ECM-specific MR contrast agent (BMS753951) non-invasive assessment of changes in remodeling of the injured mouse carotid wall has become feasible.

2125 In vivo molecular MRI of carotid artery injury in mice using an elastin-binding contrast agent