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Ischemic cardiomyopathy resulting from LV remodeling and conversion of myocytes to scar tissue is the eventual scenario in severe coronary disease. A candidate treatment for this condition is therapeutic angiogenesis. A percutaneous transendocardial approach to therapeutic angiogenesis in ischemic myocardium aims to: 1) achieve locally effective concentration of therapy; 2) minimize side-effects associated with systemic distribution; 3) minimize the effect of blood enzymes on genes and 4) eliminate open-chest surgery and extended hospitalization.

308 MR guidance and monitoring of intramyocardial delivery of VEGF Gene in coronary artery occlusion in canine model