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IL-17 producing T-cells (Th17) were recently defined as a new, pro-inflammatory T-cell subset and are considered to have a key role in autoimmune diseases.  Importantly, it was recently described that anti-inflammatory regulatory T-cells (Treg) are able to convert to pro-inflammatory Th17 cells (“Plasticity”) and vice versa. Little is known about the Th17 response or plasticity in ANCA-associated vasculitis (AAV). Therefore, we investigated Th17 responses in AAV.

Patients with non-relapsing ANCA-associated vasculitis have increased numbers of circulating IL-10 producing Th17 cells