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Polymorphisms in genes involved in antibody-dependent cellular cytotoxicity and apoptosis have been associated with inter-individual differences in the response to anti-TNF agent infliximab in arthritides. TRAILR1 and TNFR1A are two genes related to the extrinsic pathway of apoptosis.

journal of translational medicine

Role of TRAILR1 and TNFR1A polymorphisms in the susceptibility and pharmacogenetics of rheumatoid arthritis and ankylosing spondylitis patients treated with infliximab