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In the presence of IL-17 psoriasis derived keratinocytes showed a significantly higher induction of the proinflammatory members IL-1F6 and IL-1F9 compared with those from healthy individuals but not of antiinflammatory members IL-1F5, IL-1F7 or IL-1F3. Both basal, as well as IL-17 induced production of IL-1F2/IL1b and IL-1F1/IL-1a were found to be significantly lower in psoriasis keratinocytes. Conclusion

Expression of IL-1 family members upon stimulation with IL-17 differs in keratinocytes derived from psoriasis patients and healthy donors