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reported fewer AEs compared to BRAFi-naive pts. Most common AEs in BRAFi-naive pts (n=63) were non-acneiform rash (89%), diarrhea (81%), photosensitivity/sunburn (70%), fatigue (67%) and liver test abnormality (59%). Most frequent grade ≥3 AEs in BRAFi-naive pts were liver test abnormality (19%), non-acneiform rash (13%), arthral

journal of translational medicine

Updated results and correlative FDG-PET analysis of a phase IB study of vemurafenib and cobimetinib (MEK inhibitor [GDC-0973]), in advanced BRAFV600- mutated melanoma (BRIM7)