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Background B cells play a crucial role in the pathogenesis of rheumatoid arthritis (RA). They are responsible for the autoantibodies formation such as rheumatoid factor (RF) and anticyclic citrullinated peptide antibodies (antiCCP) and the production of cytokines, act as antigen presenting cells and regulate T cell functions. Rituximab (RTX), murine monoclonal antibody which selectively targets CD20-positive B-cells, has proved to be an efective and safe therapy for active RA. Initially it was used in seropositive RA, but considering the other functions of B cells, it is logical to think that it is also useful in seronegative forms.

Seronegative and seropositive rheumatoid arthritis treated with rituximab