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Background Autoantibodies (Abs) to SSA/Ro recognize two ribonucleoproteins of 52and 60-kDa. Ro52 antigen is an E3ubiquitin-ligase. Anti-Ro52 Abs are present in patients with a broad spectrum of autoimmune diseases. Usually these Abs are in association with anti-Ro60 in lupus erythematosus (SLE) and Sjogren syndrome (SS). However, isolated anti-Ro52 is frequently present in inflammatory myositis.

Analysis of autoantibodies against Ro52/Ro60 in patients with suspected diagnosis of autoimmune systemic disease