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Background Thymic Stromal Lymphopoietin (TSLP) is a potent immunomodulatory cytokine involved in Th2-mediated immune responses and homeostatic T-cell expansion. Reduced TSLP expression by intestinal epithelial cells was recently shown to lead to reduced Th2 responses and development of Th1-mediated experimental colitis. Additionally, TSLP is described as a proinflammatory factor in autoimmune diseases. TSLP expression was studied in salivary glands of primary Sjogren’s syndrome (pSS) patients as compared to non-SS Sicca (nSS) patients and the relationship to localand systemic disease parameters was examined.

journal of translational medicine

Decreased expression of TSLP in labial salivary glands of patients with primary Sjögren’s syndrome is associated with local- and systemic disease parameters