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Background  Calprotectin consists of the Ca 2+ -binding proteins S100a8 and S100a9 that are induced in epithelial cells in response to tissue damage and infection. Both proteins are also secreted by activated innate immune cells and numerous studies demonstrate their crucial role in pathological conditions of acute and chronic inflammation.    Results  Here, we established a conditional mouse model with simultaneous  S100a8  and  S100a9  transgene expression in hepatocytes ( TgS100a8a9   hep  ) under the control of doxycycline to unravel the role of epithelial-derived Calprotectin on tissue homeostasis and inflammation.  TgS100a8a9   hep   mice displayed a significant enrichment of neutrophils in peripheral blood and tissues with high blood content. Interestingly,  Cxcl1  transcription was significantly induced in the liver of  TgS100a8a9   hep   mice and primary hepatocytes derived thereof as compared to Control mice, accompanied by an increase of Cxcl1 serum levels. However, expression of other chemokines with a known function in neutrophil mobilization from the bone marrow, e.g. Csf3 and Cxcl2, was not altered. Doxycycline treatment of  TgS100a8a9   hep   mice reduced  Cxcl1  expression in the liver and resulted in normal numbers of neutrophils.    Conclusion  In summary, our data demonstrate for the first time that hepatocyte-specific S100a8 and S100a9 expression induces a systemic mobilization of neutrophils by a specific activation of Cxcl1 transcription in the liver.

Hepatocyte-specific S100a8 and S100a9 transgene expression in mice causes Cxcl1 induction and systemic neutrophil enrichment