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Background  The aim of this study was to determine the relationship between a purported luteinizing hormone/chorionic gonadotropin ( LHCGR ) high function polymorphism (rs4539842/ ins LQ) and outcome to controlled ovarian hyperstimulation (COH).    Methods  This was a prospective study of 172 patients undergoing COH at the Fertility and IVF Center at GWU. DNA was isolated from blood samples and a region encompassing the  ins LQ polymorphism was sequenced. We also investigated a polymorphism (rs4073366 G > C) that was 142 bp from  ins LQ. The association of the  ins LQ and rs4073366 alleles and outcome to COH (number of mature follicles, estradiol level on day of human chorionic gonadotropin (hCG) administration, the number of eggs retrieved and ovarian hyperstimulation syndrome (OHSS)) was determined.    Results  Increasing age and higher day 3 (basal) FSH levels were significantly associated with poorer response to COH. We found that both  ins LQ and rs4073366 were in linkage disequilibrium (LD) and no patients were homozygous for both recessive alleles ( ins LQ/ ins LQ; C/C). The  ins LQ variant was not significantly associated with any of the main outcomes to COH. Carrier status for the rs4073366 C variant was associated ( P  = 0.033) with an increased risk (OR 2.95, 95% CI = 1.09-7.96) of developing OHSS.    Conclusions  While age and day 3 FSH levels were predictive of outcome, we found no association between  ins LQ and patient response to COH. Interestingly, rs4073366 C variant carrier status was associated with OHSS risk. To the best of our knowledge, this is the first report suggesting that  LHCGR  genetic variation might function in patient risk for OHSS.

reproductive biology and endocrinology

Association between the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) rs4073366 polymorphism and ovarian hyperstimulation syndrome during controlled ovarian hyperstimulation