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Background  High circulating luteinizing hormone (LH) level is a typical biochemical feature of polycystic ovary syndrome (PCOS) whose pathophysiology is still unclear. Certain mutations of LH and LH receptor (LHR) may lead to changes in bioactivity of these hormones. The aim of this study was determine the role of the LH and LHR polymorphisms in the pathogenesis of PCOS using a genetic approach.    Methods  315 PCOS women and 212 controls were screened for the gene variants of  LH  G1052A and  LHR  rs61996318 polymorphisms by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).    Results  PCOS patients had significantly more A allele frequency of  LH  G1052A mutations than controls (p=0.001). Within PCOS group, carriers of  LH  1052A allele had lower LH (p=0.05) and higher fasting glucose levels (p=0.04). No subjects were identified with  LHR  rs61996318 polymorphisms. A new  LHR  single nucleotide polymorphism (SNP) was found without clear association with PCOS.    Conclusions  Results suggested  LH  G1052A mutation might influence PCOS susceptibility and phenotypes.

Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome