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Background  Primary prevention of breast cancer through prophylactic mastectomy can reduce the risk of malignancy in high-risk individuals. No type of mastectomy completely removes all breast tissue, but a subcutaneous mastectomy leaves more tissue  in situ  than does a simple mastectomy.    Case presentation  We report a case of invasive breast cancer in a  BRCA2 -positive woman 33 years after bilateral subcutaneous mastectomy. To our knowledge, only one case of primary breast cancer after prophylactic mastectomy in a  BRCA1 -positive patient has been reported in the literature and none in  BRCA2 -positive individuals.    Conclusion  Careful documentation and long follow-up is essential to fully assess the benefits and risks of preventive surgical procedures in  BRCA1  and  BRCA2  mutation carriers.

Invasive breast cancer following bilateral subcutaneous mastectomy in a BRCA2 mutation carrier: a case report and review of the literature