English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  We examined preoperative kinesin II-associated protein ( KAP1 ), TIMP metallopeptidase inhibitor 1 ( TIMP1 ) and stanniocalcin 2 ( STC2 ) expression levels in patients with gastric cancers to assess their clinical application for diagnosing and monitoring diseases.    Methods  Real-time reverse transcription-polymerase chain reaction was used to detect the expression levels of  KAP1 ,  TIMP1 ,  STC2 , talin 2 ( TLN2 ), sushi-repeat-containing protein, X-linked 2 ( SRPX2 ) and secreted protein, acidic, cysteine-rich ( SPARC ) in the patients’ peripheral blood karyocytes. The data were analyzed with receiver operating characteristics (ROC) curves.    Results  A total of 112 patients with gastric cancer, 42 patients with recurrence and 107 healthy volunteers were recruited. There were significant correlations between  KAP1 ,  TIMP1  and  STC2  levels, and TNM tumor stages and distant metastases. The area under the ROC curves (AUC) of  KAP1  was 0.803 ± 0.040 ( P  = 0.0001), the AUC of  TIMP1  was 0.767 ± 0.043 ( P  = 0.0001) and the AUC of  STC2  was 0.769 ± 0.045 ( P  = 0.0001), thus differentiating preoperative gastric cancer patients from healthy volunteers by ROC curve analysis. The AUC of  STC2  was 0.739 ± 0.070 ( P  = 0.004) and the AUC of  KAP1  was 0.418 ± 0.088 ( P  = 0.319), thus differentiating recurrence of gastric cancer from healthy volunteers by ROC curve analysis. High  TIMP1  and  STC2  expression levels were suspected to be poor prognostic factors of disease recurrence in patients with gastric cancer.    Conclusions   KAP1 ,  TIMP1  and  STC2  expression levels may be potential biomarkers for the screening, diagnosis, prognosis and surveillance of gastric cancer.

Clinical utility of measuring expression levels of KAP1, TIMP1 and STC2 in peripheral blood of patients with gastric cancer