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Background  The histopathological and molecular heterogeneity of normal tissue adjacent to cancerous tissue (NTAC) and normal tissue adjacent to benign tissue (NTAB), and the availability of limited specimens make deciphering the mechanisms of carcinogenesis challenging. Our goal was to identify histogenetic biomarkers that could be reliably used to define a transforming fingerprint using RNA  in situ  hybridization.    Methods  We evaluated 15 tumor-related RNA  in situ  hybridization biomarkers using tumor microarray and samples of seven tumor-adjacent normal tissues from 314 patients. Biomarkers were determined using comprehensive statistical methods (significance of support vector machine-based artificial intelligence and area under curve scoring of classification distribution).    Results   TP53  was found to be a most reliable index ( P  <10 -7 ; area under curve >87%) for distinguishing NTAC from NTAB, according to the results of a significance panel ( BCL10 ,  BECN1 ,  BRCA2 ,  FITH ,  PTCH11  and  TP53 ).    Conclusions  The genetic alterations in  TP53  between NTAC and NTAB may provide new insight into the field of cancerization and tumor transformation.

world journal of surgical oncology

Novel cancerization marker, TP53, and its role in distinguishing normal tissue adjacent to cancerous tissue from normal tissue adjacent to benign tissue