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The mouse spot test, an  in vivo  mutation assay, has been used to assess a number of chemicals. It is at present the only  in vivo  mammalian test system capable of detecting somatic gene mutations according to OECD guidelines (OECD guideline 484). It is however rather insensitive, animal consuming and expensive type of test. More recently several assays using transgenic animals have been developed. From data in the literature, the present study compares the results of  in vivo  testing of over twenty chemicals using the mouse spot test and compares them with results from the two transgenic mouse models with the best data base available, the  lacI  model (commercially available as the Big Blue ®  mouse), and the  lacZ  model (commercially available as the Muta™ Mouse). There was agreement in the results from the majority of substances. No differences were found in the predictability of the transgenic animal assays and the mouse spot test for carcinogenicity. However, from the limited data available, it seems that the transgenic mouse assay has several advantages over the mouse spot test and may be a suitable test system replacing the mouse spot test for detection of gene but not chromosome mutations  in vivo .

Mutagenicity testing with transgenic mice. Part II: Comparison with the mouse spot test.