English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background  Conspicuous facial pores are therapeutic targets for cosmeceuticals. Here we examine the effect of topical fullerene on conspicuous facial pores using a new image analyser called the VISIA ®  system. Ten healthy Japanese females participated in this study, and they received applications of 1% fullerene lotion to the face twice a day for 8 weeks.    Findings  Fullerene lotion significantly decreased conspicuous pores by 17.6% (p < 0.05, Wilcoxon signed-rank test) after an 8-week treatment. A self-administered questionnaire indicated that this reduction achieved cosmetically appreciable effects. In addition, to investigate the mechanism of effect of fullerene, we examined its effect on UVB-induced prostaglandin E 2  (PGE 2 ) production in reconstructed human epidermis (RhE). The results showed that irradiation of RhE with 1000 mJ/cm 2  increased PGE 2  production by 62.3% (p < 0.05, Mann-Whitney  U -test) and the addition of 28 μM fullerene significantly suppressed the UVB-induced PGE 2  production by 18.3% (p < 0.05).    Conclusions  Fullerene lotion significantly decreases conspicuous facial pores after an 8-week treatment possibly through the suppression of PGE 2  production in the epidermis.

Reduction of conspicuous facial pores by topical fullerene: possible role in the suppression of PGE2 production in the skin