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Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies in Japan. Invasion and metastasis of HCC are frequently observed during the development of HCCs, and are regulated by matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs). We have previously reported the strong expression of TIMP-1 and TIMP-2, and cellular localization of the transcripts in HCCs [1]. But the mechanisms of invasion and metastasis of HCCs, and particularly the role of TIMPs are still unclear. The purpose of this study was to examine the tissue concentration of the TIMP-1 and to study the potential involvement of TIMP-1 in the development of HCCs.

Elevated levels of tissue inhibitor of metalloproteinases (TIMPS) in human hepatocellular carcinomas.