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Luminol amplified chemiluminescence is widely used for the sensitive detection of reactive oxygen species (ROS) production in cells such as polymorphonuclear leucocytes and macrophages [1]. However, little work in this field has been done in Kupffer cells (KC). Cellular immunity is primarily responsible for Treponema Pallidum clearance and resolution of the early lesions [2]. However, phagocytosis proceeds much slower than with other bacteria [3]. Activated Kupffer cells trigger a process called the respiratory burst, involving an increase in cellular oxygen consumption and the production of ROS, which are cytotoxic for a variety of microorganisms and contribute to deterioration of hepatic circulation. At present, there are not studies in the literature about the phagocytosis of T. pallidum by Kupffer cells and about the ability of the spirochete to induce the production of ROS by KC. In this study, we analyzed the interaction of T. pallidum with isolated rat Kupffer cells in vitro.

Chemiluminescence detection of reactive oxygen species in isolated Kupffer cells during phagocytosis of Treponema pallidum.