English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Under physiological conditions, hepatic stellate cells store 80 % of the total vitamin A in the whole body as retinyl palmitate in lipid droplets in the cytoplasm, and regulate both transport and storage of vitamin A [1-3].  It has been demonstrated that animal or human individuals exposed to drugs such as methadone, prednisone and phenobarbital, antiepileptics [4], and xenobiotics like the environmental contaminants DDT, PCD and dioxins have dramatic changes in their retinoid metabolism and function.  Recent data demonstrate that top predators among Svalbard mammals and birds like polar bear, arctic fox and glaucous gull accumulate relatively large amounts of persistent organic pollutants [5]. Since it has been reported that vitamin A accumulates at near toxic doses in some arctic predators [6] and recent data suggest that PCB and DDT may reduce the threshold for vitamin A-toxicity [7], an increasing accumulation of persistent organic pollutants might eventually precipitate vitamin A-toxicity in these animals. To elucidate the possibility of vitamin A-related toxicity in arctic predators, we have performed a systematic characterization of the hepatic vitamin A-storage, which is the best index of the vitamin A-status, in mammals of the Svalbard archipelago.

Decreased Capacity for Vitamin A Storage in Hepatic Stellate Cells for Arctic Animals.