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Background  The novel compound  1a  is one of the isoflavone fatty acid esters. In order to investigate the anti-obesity effect of compound  1a  and its potential mechanism of influence in adipocyte differentiation, Obese male C57BL/6J mice induced by high-fat diet (HFD) and rat preadipocytes (3T3-L1 cell) were used.    Methods  After 4-week HFD induction, the obese model was made successfully. After treatment with compound  1a , mice plasma biochemistry parameters were analyzed. In addition, mice hepatic tissue slice was observed. In  in vitro  research, 3T3-L1 cell differentiation by Oil-Red-O staining and adipocyte apoptosis was detected by flow cytometry.    Results  The  in vivo  results implied that compound  1a  significantly decreased the body weight, white adipose tissue weight of obesity mice(p < 0.05), reduced leptin and TG in plasma(p < 0.05), elevated HDL-C in serum(p < 0.05). The  in vitro  results suggested that compound  1a  could significantly suppress the adipocyte viability and lipid accumulation in the differentiation of preadipocyte, and induce apoptosis in both preadipocytes and mature adipocytes(p < 0.05).    Conclusion  Compound  1a  regulates serum lipid profiles, decreases adipose tissue mass and body weight gain by inducing adipocyte apoptosis in high fat diet induced mice. Thus, it may be used to treat obese patients with hypercholesterolemia and hypertriglyceridemia.

Anti-obesity effect of an isoflavone fatty acid ester on obese mice induced by high fat diet and its potential mechanism