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Background  Oxidative damage has been proposed as a possible mechanism involved in lead toxicity, specially affecting the liver and kidney. Previous studies have shown the antioxidant effect of  Spirulina maxima  in several experimental models of oxidative stress. The current study was carried out to evaluate the antioxidant activity of  Spirulina maxima  against lead acetate-induced hyperlipidemia and oxidative damage in the liver and kidney of male rats. Control animals were fed on a standard diet and did not receive lead acetate (Control group). Experimental animals were fed on a standard laboratory diet with or without  Spirulina maxima  5% in the standard laboratory diet and treated with three doses of lead acetate (25 mg each/weekly, intraperitoneal injection) (lead acetate with  Spirulina , and lead acetate without  Spirulina  groups).    Results  The results showed that  Spirulina maxima  prevented the lead acetate-induced significant changes on plasma and liver lipid levels and on the antioxidant status of the liver and kidney. On the other hand,  Spirulina maxima  succeeded to improve the biochemical parameters of the liver and kidney towards the normal values of the Control group.    Conclusions  It was concluded that  Spirulina maxima  has protective effects on lead acetate-induced damage, and that the effects are associated with the antioxidant effect of  Spirulina .

Protective effects of Spirulina maxima on hyperlipidemia and oxidative-stress induced by lead acetate in the liver and kidney