English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background  The long-lasting and abundant blooming of  Pelagia noctiluca  in Tunisian coastal waters compromises both touristic and fishing activities and causes substantial economic losses. Determining their molecular mode of action is, important in order to limit or prevent the subsequent damages. Thus, the aim of the present study was to investigate the propensity of  Pelagia noctiluca  venom to cause oxidative damage in HCT 116 cells and its associated genotoxic effects.    Results  Our results indicated an overproduction of ROS, an induction of catalase activity and an increase of MDA generation. We looked for DNA fragmentation by means of the comet assay. Results indicated that venom of  Pelagia noctiluca  induced DNA fragmentation. SDS-PAGE analysis of  Pelagia noctiluca  venom revealed at least 15 protein bands of molecular weights ranging from 4 to 120 kDa.    Conclusion  Oxidative damage may be an initiating event and contributes, in part, to the mechanism of toxicity of  Pelagia noctiluca  venom.

lipids in health and disease

Induction of cytotoxicity of Pelagia noctiluca venom causes reactive oxygen species generation, lipid peroxydation induction and DNA damage in human colon cancer cells