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Background  Expression levels of the cell surface glycoprotein, CD7, and the serine protease, elastase 2 (ELA2), in the leukemic cells of patients with chronic myeloid leukemia (CML) have been associated with clinical outcome. However, little is known about the mechanisms that underlie the variable expression of these genes in the leukemic cells.    Results  To address this question, we compared the level of their expression with the DNA methylation and histone acetylation status of 5' sequences of both genes in leukemic cell lines and primitive (lin - CD34 + ) leukemic cells from chronic phase CML patients. DNA methylation of the  ELA2  gene promoter did not correlate with its expression pattern in lin - CD34 +  cells from chronic phase CML patient samples even though there was clear differential DNA methylation of this locus in  ELA2 -expressing and non-expressing cell lines. In contrast, we found a strong relation between CD7 expression and transcription-permissive chromatin modifications, both at the level of DNA methylation and histone acetylation with evidence of hypomethylation of the  CD7  promoter region in the lin - CD34 +  cells from CML patients with high CD7 expression.    Conclusion  These findings indicate a link between epigenetic modifications and CD7 expression in primitive CML cells.

Expression of the leukemic prognostic marker CD7 is linked to epigenetic modifications in chronic myeloid leukemia