English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A single nucleotide polymorphism (SNP) rs6983267, located within the 8q24 region, is strongly associated with risk of colorectal and prostate cancer. It has been suggested that the mechanism of this association is related to differential interaction of TCF7L2 protein (previously known as TCF-4) with alleles of rs6983267, influencing the expression of a well-known oncogene,  MYC , located 335 Kb telomeric. Here, we tested the correlation between mRNA expression of  MYC  and several alternatively spliced forms of  TCF7L2  in 117 non-cancer colon samples. We observed a strong correlation (r = 0.60, p < 10 -6 ) between expression of  MYC  and a unique splicing form of  TCF7L2 . The level of  MYC  expression in these samples was associated with expression of some  TCF7L2  splicing forms but not with genotypes of rs6983267, or interaction of rs6983267 with  TCF7L2  expression. These findings suggest that some splicing forms of  TCF7L2  may be functionally important for regulation of  MYC  expression in colon tissue but this regulation is not directly dependent on rs6983267.

No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue