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Background  Although the association between exposure to particulate matter and health is well established, there remains uncertainty as to whether certain chemical components are more harmful than others. We explored whether the association between cause-specific hospital admissions and PM 2.5  was modified by PM 2.5  chemical composition.    Methods  We estimated the association between daily PM 2.5  and emergency hospital admissions for cardiac causes (CVD), myocardial infarction (MI), congestive heart failure (CHF), respiratory disease, and diabetes in 26 US communities, for the years 2000-2003. Using meta-regression, we examined how this association was modified by season- and community-specific PM 2.5  composition, controlling for seasonal temperature as a surrogate for ventilation.    Results  For a 10 μg/m 3  increase in 2-day averaged PM 2.5  concentration we found an increase of 1.89% (95% CI: 1.34- 2.45) in CVD, 2.25% (95% CI: 1.10- 3.42) in MI, 1.85% (95% CI: 1.19- 2.51) in CHF, 2.74% (95% CI: 1.30- 4.2) in diabetes, and 2.07% (95% CI: 1.20- 2.95) in respiratory admissions. The association between PM 2.5  and CVD admissions was significantly modified when the mass was high in Br, Cr, Ni, and Na + , while mass high in As, Cr, Mn, OC, Ni, and Na +  modified MI, and mass high in As, OC, and SO 4  2-  modified diabetes admissions. For these species, an interquartile range increase in their relative proportion was associated with a 1-2% additional increase in daily admissions per 10 μg/m 3  increase in mass.    Conclusions  We found that PM 2.5  mass higher in Ni, As, and Cr, as well as Br and OC significantly increased its effect on hospital admissions. This result suggests that particles from industrial combustion sources and traffic may, on average, have greater toxicity.

Fine particulate air pollution and its components in association with cause-specific emergency admissions