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Background  Polymorphisms in  GSTT1 ,  GSTM1  and  GSTP1  impact detoxification of carcinogens by GSTs and have been reported to increase susceptibility to environmentally related health outcomes. Individual factors in arsenic biotransformation may influence disease susceptibility. GST activity is involved in the metabolism of endogenous and exogenous compounds, including catalyzing the formation of arsenic-GSH conjugates.    Methods  We investigated whether polymorphisms in  GSTT1 ,  GSTP1  and  GSTM1  were associated with risk of skin lesions and whether these polymorphisms modify the relationship between drinking water arsenic exposure and skin lesions in a case control study of 1200 subjects frequency matched on age and gender in community clinics in Pabna, Bangladesh in 2001–2002.    Results and discussion   GSTT1  homozygous  wildtype  status was associated with increased odds of skin lesions compared to the null status (OR1.56 95% CI 1.10–2.19). The  GSTP1 GG  polymorphism was associated with greater odds of skin lesions compared to  GSTP1 AA , (OR 1.86 (95%CI 1.15–3.00). No evidence of effect modification by  GSTT1 ,  GSTM1  or  GSTP1  polymorphisms on the association between arsenic exposure and skin lesions was detected.    Conclusion   GSTT1 wildtype  and  GSTP1 GG  are associated with increased risk of skin lesions.

A case-control study of GST polymorphisms and arsenic related skin lesions