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Background  Recent observations in  in vitro  and  in vivo  models suggest that arsenic (As) is an endocrine disruptor at environmentally-relevant levels. When exposed to As, male rats and mice show steroidogenic dysfunction that can lead to infertility. However, the possible effects of As on human male semen quality remain obscure.    Methods  We monitored the profile of As species in the urine of a reproductive-age human cohort and assessed its association with semen quality. Men ( n  = 96) were recruited in an infertility clinic from July 2009 to August 2010 in the Affiliated Hospital of Chongqing Institute for Population and Family Planning. Five urinary As species were analyzed by high-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). Clinical information on the semen volume, sperm concentration and motility was employed to catalogue and evaluate semen quality according to WHO guidelines. As species concentrations in addition to other continuous variables were dichotomized by the medians and modelled as categorical variables in order to explore using the binary logistic regression possible associations between As exposure and semen quality.    Results  Urinary concentrations (geometric mean ± SD, μg g -1  creatinine) of different As species were 7.49 (±24.8) for AsB, 20.9 (±13.7) for DMA, 2.77 (±3.33) for MMA, and 4.03 (±3.67) for As i  (As i  III  and As i  V ). DMA concentrations above the median were significantly associated with below-reference sperm concentrations ( P  =0.02) after adjusting for age, body mass index (BMI), abstinence, smoking and drinking habits. In addition, smoking was positively associated with MMA.    Conclusion  Reduced parameters in human semen quality are positively associated with As exposure in a reproductive-age Chinese cohort.

Environmental exposure to arsenic may reduce human semen quality: associations derived from a Chinese cross-sectional study