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Background/Aims  Matrix Metalloproteinases 2 is a key molecule in cellular invasion and metastasis. Mitochondrial ROS has been established as a mediator of MMP activity. Coenzyme Q 10  contributes to intracellular ROS regulation. Coenzyme Q 10  beneficial effects on cancer are still in controversy but there are indications of Coenzyme Q 10  complementing effect on tamoxifen receiving breast cancer patients.    Methods  In this study we aimed to investigate the correlation of the effects of co-incubation of coenzyme Q10 and N-acetyl-L-cysteine (NAC) on intracellular H2O2 content and Matrix Metalloproteinase 2 (MMP-2) activity in MCF-7 cell line.    Results and Discussion  Our experiment was designed to assess the effect in a time and dose related manner. Gelatin zymography and Flowcytometric measurement of H2O2 by 2'7',-dichlorofluorescin-diacetate probe were employed. The results showed that both coenzyme Q10 and N-acetyl-L-cysteine reduce MMP-2 activity along with the pro-oxidant capacity of the MCF-7 cell in a dose proportionate manner.    Conclusions  Collectively, the present study highlights the significance of Coenzyme Q 10  effect on the cell invasion/metastasis effecter molecules.

Exogenous coenzyme Q10 modulates MMP-2 activity in MCF-7 cell line as a breast cancer cellular model