English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Pro

Presents the zaia usage as premium feature

ZAIA

Presents AI Discovery search usage as a premium feature

AI Discovery

Presents AI Discovery explain and summary usage as a premium feature

Content Analysis

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Presents the pdf analysis as premium feature

PDF Analysis

1500 Top-up

3000 Top-up

Zendy Basic

2500 Top-up

Zendy Unlimited

Presents the access of premium content as premium feature

Premium Content

Immunological protection against Plasmodium falciparum blood stages is mainly antibody mediated [1,2]. Variant surface antigens (VSA) expressed on the surface of P. falciparum-infected red blood cells constitute a key for parasite sequestration and immune evasion [3]. In distinct malaria clinical presentations, as placental malaria, specific antibody response against VSA provides protection [4].  In the current study, we investigated in distinct clinical groups of malaria patients, the antibody response specifically directed against VSA expressed by parasites isolated from a given clinical presentation, and particularly isolates obtained from cerebral malaria (CM) patients. Plasma and isolates were obtained from four groups of Beninese subjects: healthy adults (HA, n = 34), patients presenting uncomplicated malaria (UM, n = 62), cerebral malaria (CM, n = 41), or pregnancy-associated malaria (PAM, n = 24). Isolates were tested for their clonality by msp1 and msp2 genotyping. The reactivity of plasma samples from each clinical group was measured by flow cytometry against parasites isolated from individuals from each clinical group.  The levels of clonality were similar in isolates from all clinical origins. In healthy adults and children presenting UM, VSAUM antibody levels were higher than VSACM antibody levels (Figure (Figure1).1). In both PAM plasma groups (primigravidae and multigravidae), antibody levels against the three types of isolates were similar. One month after infection the level of anti-VSA antibodies able to recognize heterologous VSACM variants was increased in CM patients. In UM patients, antibody levels directed against heterologous VSAUM were similar during the infection and one month later (Figure (Figure22).    Figure 1  Relative levels of VSA specific IgG to heterologous P.falciparum isolates according to the clinical origin of the P. falciparum isolates, and to the plasma group. PG: primigravidae, MG: multigravidae. Errors bars indicate standard errors. Groups were ...      Figure 2  Acquisition of VSA-specific IgG during the month following P. falciparum infection in plasmas samples from UM (n = 121) and CM (n = 56) patients. UM (A, B) or CM (C, D) plasma samples were tested against P. falciparum isolates from UM patients (A, D) ...    The existence of shared VSACM epitopes was shown but does not necessarily involve prevalent epitopes. Prevalence is more probably due to a fine balance between transmission intensity, antibody repertoire and environmental factors.

Variant surface antigens in cerebral malaria: distinct from others and similar to each other?