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Background  Many countries are scaling up malaria interventions towards elimination. This transition changes demands on malaria diagnostics from diagnosing ill patients to detecting parasites in all carriers including asymptomatic infections and infections with low parasite densities. Detection methods suitable to local malaria epidemiology must be selected prior to transitioning a malaria control programme to elimination. A baseline malaria survey conducted in Temotu Province, Solomon Islands in late 2008, as the first step in a provincial malaria elimination programme, provided malaria epidemiology data and an opportunity to assess how well different diagnostic methods performed in this setting.    Methods  During the survey, 9,491 blood samples were collected and examined by microscopy for  Plasmodium  species and density, with a subset also examined by polymerase chain reaction (PCR) and rapid diagnostic tests (RDTs). The performances of these diagnostic methods were compared.    Results  A total of 256 samples were positive by microscopy, giving a point prevalence of 2.7%. The species distribution was 17.5%  Plasmodium falciparum  and 82.4%  Plasmodium vivax . In this low transmission setting, only 17.8% of the  P. falciparum  and 2.9% of  P. vivax  infected subjects were febrile (≥38°C) at the time of the survey. A significant proportion of infections detected by microscopy, 40% and 65.6% for  P. falciparum  and  P. vivax  respectively, had parasite density below 100/μL. There was an age correlation for the proportion of parasite density below 100/μL for  P. vivax  infections, but not for  P. falciparum  infections. PCR detected substantially more infections than microscopy (point prevalence of 8.71%), indicating a large number of subjects had sub-microscopic parasitemia. The concordance between PCR and microscopy in detecting single species was greater for  P. vivax  (135/162) compared to  P. falciparum  (36/118). The malaria RDT detected the 12 microscopy and PCR positive  P. falciparum , but failed to detect 12/13 microscopy and PCR positive  P. vivax  infections.    Conclusion  Asymptomatic malaria infections and infections with low and sub-microscopic parasite densities are highly prevalent in Temotu province where malaria transmission is low. This presents a challenge for elimination since the large proportion of the parasite reservoir will not be detected by standard active and passive case detection. Therefore effective mass screening and treatment campaigns will most likely need more sensitive assays such as a field deployable molecular based assay.

malaria journal

A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting