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Background  The evasion of host immune response by the human malaria parasite  Plasmodium falciparum  has been linked to expression of a range of variable antigens on the infected erythrocyte surface. Several genes are potentially involved in this process with the  var ,  rif  and  stevor  multigene families being the most likely candidates and coding for rapidly evolving proteins. The high sequence diversity of proteins encoded by these gene families may have evolved as an immune evasion strategy that enables the parasite to establish long lasting chronic infections. Previous findings have shown that the hypervariable region (HVR) of STEVOR has significant sequence diversity both within as well as across different  P. falciparum  lines. However, these studies did not address whether or not there are ancestral  stevor  that can be found in different parasites.    Methods  DNA and RNA sequences analysis as well as phylogenetic approaches were used to analyse the  stevor  sequence repertoire and diversity in laboratory lines and Kilifi (Kenya) fresh isolates.    Results  Conserved  stevor  genes were identified in different  P. falciparum  isolates from different global locations. Consistent with previous studies, the HVR of the  stevor  gene family was found to be highly divergent both within and between isolates. Importantly phylogenetic analysis shows some clustering of  stevor  sequences both within a single parasite clone as well as across different parasite isolates.    Conclusion  This indicates that the ancestral  P. falciparum  parasite genome already contained multiple  stevor  genes that have subsequently diversified further within the different  P. falciparum  populations. It also confirms that STEVOR is under strong selection pressure.

Characterization of the repertoire diversity of the Plasmodium falciparum stevor multigene family in laboratory and field isolates