English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background  Malaria is the most significant human parasitic disease, and yet understanding of the energy metabolism of the principle pathogen,  Plasmodium falciparum , remains to be fully elucidated. Amino acids were shown to be essential nutritional requirements since early times and much of the current knowledge of  Plasmodium  energy metabolism is based on early biochemical work, performed using basic analytical techniques, carried out almost exclusively on human plasma with considerable inter-individual variability.    Methods  In order to further characterize the fate of amino acid metabolism in malaria parasite, multivariate analysis using statistical modelling of amino acid concentrations (aminogram) of plasma and liver were determined in host infected with rodent malaria parasite,  Plasmodium yoelii .    Results and conclusion  Comprehensive and statistical aminogram analysis revealed that  P. yoelii  infection caused drastic change of plasma and liver aminogram, and altered intra- and inter-correlation of amino acid concentration in plasma and liver. These findings of the interactions between amino acids and  Plasmodium  infection may provide insight to reveal the interaction between nutrients and parasites.

Multivariable analysis of host amino acids in plasma and liver during infection of malaria parasite Plasmodium yoelii