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Background Antibodies mediate naturally acquired immunity to the asexual blood stages of human malaria. Merozoite surface antigen-specific antibodies inhibit the in vitro growth and development of the parasite P. falciparum, although the functional mechanisms of this inhibition are not fully understood. In this study, we investigated the functional mechanisms of in vitro growth inhibition by antibodies to merozoite surface protein 3.3C.

Merozoite surface protein 3.3C-specific antibodies block the intraerythrocytic development of Plasmodium falciparum and induce parasite apoptosis