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Background Antimalarial efficacy is dependent on administration of a curative dose determined by the pharmacokinetic and dynamic profile of the drug and the age and weight of the patient. Optimal dosing strategies are frequently compromised by pragmatic constraints resulting in patients receiving a wide range of mg/kg dose. WWARN has established a scientific research project aiming at pooling all relevant patient level data from ACTs studies conducted in malaria endemic areas. This study aimed at investigating the consequences of variance in dosing strategies of key ACTs and their effect on clinical efficacy.

The power of pooled analysis to inform optimal dosing strategies for Artemisinin Combination Therapies (ACTs)