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Results In total 65,078 patients were enrolled into 213 clinical trials of artemisinin-containing regimens with 413 treatment arms containing either an artemisinin derivative alone (n=26) or in combination with a partner drug (n=387). The proportion of patients remaining parasitaemic at 24, 48 and 72 hours was documented in 115 (28%), 167 (40%) and 153 (37%) treatment arms, respectively. Excluding resistance studies in Cambodia, the median proportion of patients still parasitaemic was 53.8% [range 3-95, IQR=30.5-69.2] at 24 hours, 6% [range 0-65.9, IQR=2-11.5] at 48 hours and 0 [range 012.6, IQR=0-2] at 72 hours. Comparing studies from 2000-2005 and 2006-2011, the median proportion of patients remaining parasitaemic at 72 hours decreased in Africa (1.6% vs. 0, p=0.0004), but increased in Asia (0.8% vs. 1.2%, p=<0.0001). Overall in 95% of these studies the proportion of patients with peripheral parasitaemia was <6% at 72 hours.

malaria journal

A systematic review of published antimalarial clinical trials: parasite clearance of artemisinin-containing regimens in the treatment of uncomplicated malaria