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Background During the intra-erythrocytic stage, Plasmodium parasites degrade hemoglobin resulting in ferriprotoporphyrin (IX) accumulation; toxic to the parasite [1]. bHematin, a synthetic polymer made from ferriprotoporphyrinIX is structurally, chemically and spectroscopically identical to purified hemozoin is used in in-vitro studies [1]. Resistance to Chloroquine, highlights the need for new drugs. Earlier attempts showed the effect of pyrimidine derivatives in in-vitro inhibition of b-hematin [2], and cisplatin complexes [3]. We concentrate on finding new molecules from natural products; (Salvia officinalis).

Wild sage (Salvia officinalis) as a potential anti-malarial drug