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Background The deep vascular sequestration of parasitized erythrocytes is a central pathological event in falciparum malaria. Variant surface antigens are encoded mainly by three multi-copy gene families, namely, var, stevor ,a ndrifin. Var is one of the most important families that plays a crucial role in antigenic variation and immune evasion. Clinical and epidemiological studies have shown that severe or complicated malaria is manifested in a limited number of patients. This indicates that a subset of these multigene families could be determinants in the manifestation of different malaria phenotypes. Recent studies have indicated the possible role of stevor (sub-telomeric variable open read), a multi-gene family, in erythrocyte invasion, antigenic variation and host cell modification, of infected erythrocytes. In this study, we describe the repertoire and diversity of members of the stevor multigene family in patients with complicated and uncomplicated malaria in India.

The repertoire diversity of the Plasmodium falciparum stevor multigene family in complicated and uncomplicated malaria in India