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Background  Urban malaria can be a serious public health problem in Africa. Human-landing catches of mosquitoes, a standard entomological method to assess human exposure to malaria vector bites, can lack sensitivity in areas where exposure is low. A simple and highly sensitive tool could be a complementary indicator for evaluating malaria exposure in such epidemiological contexts. The human antibody response to the specific  Anopheles  gSG6-P1 salivary peptide have been described as an adequate tool biomarker for a reliable assessment of human exposure level to  Anopheles  bites. The aim of this study was to use this biomarker to evaluate the human exposure to  Anopheles  mosquito bites in urban settings of Dakar (Senegal), one of the largest cities in West Africa, where  Anopheles  biting rates and malaria transmission are supposed to be low.    Methods  One cross-sectional study concerning 1,010 (505 households) children (n = 505) and adults (n = 505) living in 16 districts of downtown Dakar and its suburbs was performed from October to December 2008. The IgG responses to gSG6-P1 peptide have been assessed and compared to entomological data obtained in or near the same district.    Results  Considerable individual variations in anti-gSG6-P1 IgG levels were observed between and within districts. In spite of this individual heterogeneity, the median level of specific IgG and the percentage of immune responders differed significantly between districts. A positive and significant association was observed between the exposure levels to  Anopheles gambiae  bites, estimated by classical entomological methods, and the median IgG levels or the percentage of immune responders measuring the contact between human populations and  Anopheles  mosquitoes. Interestingly, immunological parameters seemed to better discriminate the exposure level to  Anopheles  bites between different exposure groups of districts.    Conclusions  Specific human IgG responses to gSG6-P1 peptide biomarker represent, at the population and individual levels, a credible new alternative tool to assess accurately the heterogeneity of exposure level to  Anopheles  bites and malaria risk in low urban transmission areas. The development of such biomarker tool would be particularly relevant for mapping and monitoring malaria risk and for measuring the efficiency of vector control strategies in these specific settings.

IgG responses to the gSG6-P1 salivary peptide for evaluating human exposure to Anopheles bites in urban areas of Dakar region, Sénégal