English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Cellular immunotherapy is a promising approach to specific treatment of cancer. Dendritic cells (DC) are the beststudied antigen presenting cells (APC) and have been tested in multiple clinical trials over the last years. To extend this strategy to clinical situations in which DC therapy might be more challenging, e.g. pediatric patients or to approaches with frequent vaccinations, we have established CD40-activated B cells (CD40-B cells) as a complementary autologous APC, due to the simple generation of large amounts of highly efficient CD40-B cells from small amounts of peripheral blood. Similar to the pharmaceutical development of DC to become a standardizable adjuvant, several important biological aspects need to be addressed for CD40-B cells prior to "product development" according to GMP conditions.

Biological characterization of CD40-activated B cells as a prerequisite for their use as cellular adjuvant in cancer vaccines