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Background T cells bearing the Gamma9/Delta2 T cell receptor (TCR) constitute two to ten percent of peripheral blood T lymphocytes. They have recently raised much interest as nonMHC restricted effector cells against a variety of tumors. Gamma/Delta T cells are known to be stimulated by phosphoantigens without the need of professional antigen presenting cells. Furthermore, it is described that incubation with phosphoantigens increases their proliferation rate rapidly.

Bisphosphonic acid acts as Gamma/Delta T cell activating antigen and has direct cytotoxic activity against pancreatic carcinoma cells